Detalhe da pesquisa
1.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res
; : 1-7, 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37362320
2.
Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 29(4): 659-663, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30638874
3.
Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 28(5): 958-962, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439904
4.
A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site.
Mol Pharmacol
; 92(3): 310-317, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28645932
5.
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.
J Pharmacol Exp Ther
; 363(3): 377-393, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954811
6.
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Bioorg Med Chem
; 25(2): 496-513, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914948
7.
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Bioorg Med Chem
; 25(20): 5490-5505, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28818462
8.
Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice.
Brain Behav Immun
; 42: 204-11, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25016199
9.
TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding.
Mol Metab
; 80: 101883, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38237896
10.
TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner.
Neuropsychopharmacology
; 2023 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38110609
11.
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
J Med Chem
; 64(15): 11090-11128, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34270254
12.
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides.
Mol Ther Nucleic Acids
; 19: 1290-1298, 2020 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32092825
13.
Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus.
J Psychopharmacol
; 33(1): 25-36, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30484737
14.
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 62(2): 831-856, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30576602
15.
Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition.
Brain Res
; 1197: 47-62, 2008 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242587
16.
Mapping the central effects of (±)-ketamine and traxoprodil using pharmacological magnetic resonance imaging in awake rats.
J Psychopharmacol
; 32(2): 146-155, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29378483
17.
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
ACS Med Chem Lett
; 9(5): 472-477, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795762
18.
Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats.
Eur J Pharmacol
; 562(3): 191-7, 2007 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17321516
19.
Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.
PLoS One
; 12(12): e0187609, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29261656
20.
NaV channel variants in patients with painful and nonpainful peripheral neuropathy.
Neurol Genet
; 3(6): e207, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29264398